Head of Laboratory
Kichigina Valentina Fedorovna
d.b.s.
(4967) 73-94-99
(4967) 73-56-35
(495) 623-74-67 (доб. 345)
The role of the hippocampal system of the brain in the mechanisms of neuronal plasticity and memory in normal and pathological conditions.
- Interneuronal interactions in the septo-hippocampal system are normal and in an experimental model of temporal lobe epilepsy.
- Neurotransplantation of the embryonic nervous tissue of the hippocampus and septum into the brain and anterior chamber of the eye to study morphological and functional plasticity and to compensate for impaired brain functions.
- The study of the morphological and functional state of the hippocampus is normal and in experimental models of temporal lobe epilepsy and Alzheimer's disease.
- Activation of homeostatic systems of the brain (endocannabinoid system and energy metabolism) as a new approach to prevent the development and compensation of impaired functions in models of neurodegenerative diseases.
- Development of computational models for the functioning of the septo-hippocampal system in normal and pathological conditions.
- Registration of local field potentials (LPP) and population spikes in the brain of awake animals.
- Intracerebral administration of pharmacological substances through a cannula associated with recording electrodes in experiments on waking animals. The cannula and electrodes are implanted during the preliminary (one week before the experiment) surgery.
- Creation of an experimental model of temporal lobe epilepsy. Animals will be given epileptogens kainic acid or pentylenetetrazole (status epileptic method). Assessment of behavioral seizures in freely moving animals will be carried out on a 6-point scale (Racine, 1972). Before and after administration of the epileptogen, electrical activity will be recorded.
- Conducting behavioral experiments. Behavior is studied in several groups of animals, normal and with pathology (with models of temporal lobe epilepsy and Alzheimer's disease).
- Studying the nature of rhythmic activity. The spectral power of theta, gamma, and ripple oscillations is estimated using the window Fourier transform, as well as Morlet wavelet analysis. The specified analysis is carried out using specially computer programs.
- Effects on the endocannabinoid system and energy metabolism.
- Registration of the neural activity of the hippocampus and its input and output structures.
- Morphological methods.
